CoGenesis® Colo
31-gene hereditary colorectal cancer test
CoGenesis® Colo is a 31-gene test for hereditary colorectal cancers. It includes genes linked to a higher chance of developing colorectal cancer: APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, TP53 genes. It helps you understand your lifetime risk of developing colorectal cancer.
- A Individuals with a personal or family history of colorectal cancer, Lynch syndrome (HNPCC), or familial adenomatous polyposis (FAP).
- Identifying carriers of pathogenic variants in hereditary colorectal cancer related genes
- Informing clinical management, including surveillance, preventive strategies
- Not intended as a diagnostic test for active cancer.
- Detecting non‑genetic or environmental causes of cancer
- Predicting exact age of onset or severity of disease
- Serving as a stand‑alone diagnostic tool without clinical correlation
1 sub-panel included:
| Step / Test | Accuracy | Notes |
|---|---|---|
| Variant calling – SNP | >99.9% | |
| Variant calling – Indel | >99% |
4mL peripheral blood (EDTA), 2mL saliva, 4 buccal swabs
Preferred sample type:
- 4mL Blood (EDTA tube),
- Codex-provided buccal swabs (4 swabs)
- Codex-provided saliva collection kit (2mL)
Saliva or buccal swab sample collection: Follow the enclosed instructions; do not eat, drink, or smoke for 30 minutes before collection.
- Insufficient DNA quantity or poor DNA quality
- Improperly labeled or contaminated samples
- Degraded specimens due to incorrect storage or transport
- Non-human samples or inappropriate specimen types
Samples must be collected and submitted by a licensed healthcare professional.
- Keep Blood samples at 4–8°C after collection; avoid freezing, deliver within 48 hours of collection.
- Saliva or buccal swabs are stability in room temperature for up to 7 days. Address: Unit 220, 2/F, Building 16W, HKSTP, Pak Shek Kok, NT, Hong Kong. Tel: +852 3008 2560
- Results may identify pathogenic, likely pathogenic, or variants of uncertain significance (VUS).
- Positive findings can inform risk‑reducing strategies and treatment options.
- Genetic counseling is recommended to help families understand implications.
Lynch syndrome carries a lifetime colorectal cancer risk of up to 80%. FAP accounts for ~1% of colorectal cancers but 100% will develop into malignant tumours. The 5-year survival rate is ~90% when caught at an early stage.
Hong Kong-based molecular diagnostics laboratory specialising in clinical genomics, precision oncology, and rare disease diagnosis. Accredited to ISO 27001 and GenQA standards.
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