CYP2C9 | CYP2C19 | CYP2D6 | HLA-A | HLA-B |
Spear BB, Heath-Chiozzi M, Huff J. Clinical application of pharmacogenetics. Trends Mol Med. 2001
Steps | Accuracy |
---|---|
DNA sequencing | 99.9% |
Variant calling – SNP | >99%*# |
Variant calling – Indel | >99%*# |
* Passed GenQA/UK NEQAS external quality assurance
# The interpretation of sequencing variants is based on the current understanding of the variants at the time it was observed, which may change over time as more information about the genes becomes available. Not all variants are represented in this report.
Disclaimer:
The interpretations and clinical annotations provided by Codex are intended solely for use by a medical professional and do not constitute medical advice by Codex. Test results shown on this report require clinical interpretation and comments by a specialist of the respective discipline. The pharmacokinetics of a drug might be affected by the dosage form and route of administration. Please consult a qualified healthcare professional before making decisions about medical conditions or before starting and stopping any prescribed treatment. The treating providers are ultimately responsible for all diagnoses and treatments. The report and recommendations are based on the guidelines provided by CPIC1 and do not take into account other genetic variants and environmental or social factors that may affect the drug response. Other factors not included in this report include, but are not limited to, environmental factors (e.g., smoking), health factors (e.g., diet), social factors, various medical conditions, and other concurrent medications. Off-label drug uses are not considered in this report. The recommendations in the report are for the corresponding drugs only, and the drug-drug interactions are not considered. As a matter of practice, Codex will routinely update its database as new information becomes available to the scientific community. Annotations and recommendations are therefore dependent on the date of generation and/or the database version used to generate that report.