CoGenesis® Colo is a 12-gene test for hereditary colorectal cancers. It includes genes linked to a higher chance of developing colorectal cancer: APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, TP53 genes. It helps you to understand your risk level of development colorectal cancer throughout your lifetime.
1 in every 20 males in Hong Kong will have colorectal cancer in their lifetime.1
1 in every 32 females in Hong Kong will have colorectal cancer in their lifetime. 1
Hereditary factors account for around 35% of colorectal cancer risk. 2
If you have 1 close relative with colorectal cancer, your chance of getting colorectal cancer is 2-3 times higher than the general population. 3
If you have tested positive for a colorectal cancer gene mutation, it does not mean you will have colorectal cancer. However, your chance of getting colorectal cancer will be higher than the general population.
What can you do if you belong to the high-risk population?
Start colorectal cancer screening tests as soon as possible
Screen for colorectal cancer more frequently
Closely watch out for any colorectal cancer symptoms
Learn about options that reduce colorectal cancer risk
The 5-year survival rate of colorectal cancer is about 90% for those who found it at an early stage. 4
American Cancer Society. Colorectal Cancer Early Detection, Diagnosis, and Staging.
# The interpretation of sequencing variants is based on the current
understanding of the variants at the time it was observed, which may change
over time as more information about the genes becomes available. Not all
variants are represented in this report.
Source:
Hong Kong Cancer Registry, Hospital Authority. Colorectal Cancer in 2018. Last updated: Oct 2020.
Monahan KJ, Bradshaw N, Dolwani S Hereditary CRC guidelines eDelphi consensus group, et alGuidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)Gut 2020;69:411-444.2
Burt R. Inheritance of Colorectal Cancer. Drug Discov Today Dis Mech. 2007;4(4):293-300. doi:10.1016/j.ddmec.2008.05.004
American Society of Clinical Oncology (ASCO). Lynch Syndrome 01/2020. https://www.cancer.net/cancer-types/lynch-syndrome
National Comprehensive Cancer Network. NCCN Guideline. Genetic/ Familial High-Risk Assessment: Colorectal.
American Cancer Society. Colorectal Cancer Causes, Risk Factors, and Prevention.
